Ryze Q and W proc the Muramana active (if toggled), causing them to deal more damage. Does this extra damage cause more "splash damage" when his ultimate is active?
Single target spells and attacks (on hit) consume 3% of current Mana to deal bonus physical damage equal to twice the amount of Mana consumed.
Ryze - Desperate Power (Ultimate):
Ryze becomes supercharged, gaining spell vamp and 80 bonus flat movement speed, and causing his spells to deal 50% of their damage to other enemies in a 200 unit radius around the original target.