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In Starcraft, the rule is: "Last man standing wins the game".
So you must destroy "all buildings" to eliminate your enemy completely. That includes all floating Terran buildings,too.
But does this include Protoss Pylons, Terran Energy Depots, and Vespene Refineries?
All buildings must be destroyed in order for a player to lose, see Blizz Rules. Note, that this does not constitute a "win" condition, only a "lose" condition. In the event that a player hits a "lose" condition, while the other player does not, the other player THEN hits a "win" condition.
This is important because in a condition where players are racing to destroy each other buildings, the one that was destroyed quicker down to the millisecond, will trigger the "lose" condition for the first player, preventing the second one from hitting a "lose" condition, doing it this way prevents a "double win" miss-hap.
It's also important to remember that buildings in flight and mid-construction are also building units counting towards the players "not-yet-lost" condition. Units like Creep tumors are considered food-cost-less units, not buildings.
Also note, that there are "stalemate" conditions, when neither player can take such action as to cause the other player into a "lose" condition, see Team Liquid Wiki
Yes every single structure must be destroyed. With a structure being any fixed, player-controlled construct that required resources to be built. That is with minerals and/or vespene gas. This category includes all constructs with the capacity of being lifted, as they're fixed constructs that become movable should the player decide to. Even while being in the lifted state they're considered buildings. Essentially every fixed colored point you see on the minimap. Only creep tumors are some sort of structure not considered a building.
