The lady that owns the Riverwood Hotel has been killing me and she is part of my quest so I can't kill her. I need to talk to her but I can't because she is killing me. What should I do?
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What platform are you using? – Ben May 4 '15 at 0:07
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Check your powers and a give effects. You're not a vampire, by any chance? – John Laviolette May 8 '15 at 2:38
You might need to restore from an earlier Save - if Delphine is attacking you, it must be that you have already done something that upset her for instance you accidently hit her with a weapon, or attacked a resident of the village.
There might be a way of correcting the problem, by paying any bounty you have, but going back to an earlier save might be far easier.
Go to Whiterun and commit a crime. Then pay the bounty or give jail time. Return to Riverwood to find your needed NPC free of any hostile actions.