Getting poisoned by the Queen Endrega is pretty much a death sentence. It comes out quickly in a spray and hits you even if you're trying to roll out of the way.
Even if I'm able to kill the other Endregas around her (which re-spawn if you save after killing them...at least I can farm experience this way), fighting the Queen one-on-one is futile and suicidal.
Which signs and strategies are especially effective?
Is it just another matter of having to have a perfect run to win the battle?