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As you know, he is the hardest boss to kill in the game. I don't really have an employed winning strategy. Any suggestions?

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  • I consider Saddler as one of the easiest bosses, the fight runs somewhat on autopilot.
    – user598527
    Jan 31, 2017 at 15:08

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It's been a while since I played Resident Evil 4, so I consulted a few game guide's for the boss sequence.

When Saddler attacks you can press dodge to avoid the attack, or prompt a quick time event to avoid the attack.

Hit Saddler with explosives. This seems to work the best. Grenade launchers or the RPG will work best. There ar explosive barrels around you can lure Saddler near to set off.

Shoot Saddler's leg eyes. These are the weak spots for shooting Saddler with guns.

When Saddler is stunned you can run up to him for a quick time event that deals extra damage.

When Saddler's health is low Ada will throw you an RPG. Make the shot count, but hit Saddler once with it and it will be all over.

Youtube Video

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