The Del Lago is a very fast and sneaky boss. The main problem is the terrain. You are stuck inside a boat, in the middle of a lake, with nothing but harpoons.
How do you overcome this obstacle?
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Well, no magic involved here. Try to avoid the obstacles when he pulls you, try to hit him with the harpoons at the same time, by aiming a little higher. When he seems to have disappeared and you auto switch to aiming mode, wait for the signal about his location and shoot as much as you can. Aim a little lower to be sure to hit him.