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The advice I've seen with regards to deathclaw defense is that endurance and weapon damage are the items that matter. I have never seen anyone explicitly say that perception does not affect damage however.

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  • I'm skeptical that endurance matters. The only factors I've seen that make a difference are HP and weapon damage.
    – user86571
    Commented Oct 22, 2015 at 18:37
  • Endurance matters only during lvl up. You gain bonus HP the higher your end is
    – SkyHiRider
    Commented Oct 22, 2015 at 23:36

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I tested a room with +5 to each special and the results were the same.

It does not matter which special is maxed, only weapon damage and HP matter.

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