In general, each DLC adds content to the game and they can all be safely installed and played at the same time. The fact that some of the foes you'll face in the wilds of Solstheim are a little tougher than those on the mainland may encourage you to face the challenges of skyrim-dragonborn a little later.
I don't generally focus specifically on the main story lines in any order, but I frequently find myself finishing the dawnguard story-line before I finish the main Skyrim story line ...
...to both cut down on the muggings by the faction I'm working against and because I find that uncontrolled vampires do more damage to the populations of my cities than do uncontrolled dragons.
The Hall of the Vigilant
The only Change that may leave you feeling that you've missed out on something is that loading skyrim-dawnguard and reaching level 10 will cause the Hall of the Vigilant to have been sacked by vampires. The location does not seem to have any quests to which you'd loose access. Though a player that intends to specialize in Heavy Armor may wish to visit for a single point of training from a book, The Knights of the Nine. There is also a Daedra Heart laying about which is rare enough to consider visiting before it's sacked.
Entertainingly enough, there is also Keeper Carcette, an Expert Restoration Trainer there to serve the 0-75 Restoration training needs of your pre-Level 10 characters. Not much of a loss as Danica Pure-Spring, of Whiterun, is a Master trainer (0-90), as is Florentius Baenius, who is added by the same DLC that kills off Carcette.
Another interesting skyrim-dawnguard change is that...
...folks don't get violently aggressive toward you if you allow yourself to become a stage 4 vampire. Personally I think it's a shame that you no longer need to manage your "hunger" if you're careless enough to allow yourself to be turned by a common vampire (not to be confused with the much smarter/cooler Vampire Lords, who will keep a stable of "Cattle" for you to feed upon).