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When completing missions and encounters in the game you are often given directions by 'ISAC'. The voice sounds like it's a computer, so my assumption is that ISAC is actually an acronym.

So what does ISAC stand for?

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ISAC stands for "Intelligent System Analytic Computer". It is confirmed at the beginning of the game, as you can see in this playthrough video at 5 minutes and 8 seconds.

It is also confirmed by the tvtropes site :

ISAC, the personal assistant AI used by Agents to give them updates and alerts stands for "Intelligent System Analytic Computer".

The Famitsu's glossary page for The Division also confirm it from what we can read from it :

■ISAC “Intelligent System Analytic Computer”の略称。膨大な情報を一元管理して伝達し、現場のエージェントをつねにサポートしてくれる。

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  • I remember that ISAC tells you what the acronym stands for when it introduces itself, if anybody wants to try to confirm it.
    – DCShannon
    Mar 17, 2016 at 0:42
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    I started a new game yesterday, and I can confirm that ISAC introduces itself as "Intelligent System Analytic Computer" in-game.
    – DCShannon
    Mar 18, 2016 at 23:19
  • I was looking for a playthrough video where he was saying that. Thanks for the confirm !
    – Izukani
    Mar 19, 2016 at 9:34

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