As Daniel Seales wrote, the picture is from the Dead Space 2.
As for the lullaby Twinkle, Twinkle, Little Star it was first featured in one of the trailers of first Dead Space called Dead Space Lullaby Trailer:
I highly recommend watching it, it is one of my favorite trailers of all time.
The trailer was also featured in the game as screensaver for the main menu, and can be heard in a few times in the actual game and in its sequel. Without spoiling anything I can tell you that the picture is referring to one of more memorable moments when it can be heard. Dead Space 1 and 2 was a great examples of a sci-fi themed survival horror, If you like such things I highly recommend trying them.