My current character is a Barbarian, and I have been playing him 100% offensively (i.e. no shield). I often switch between dual weapons and 2-hand weapons, depending on what the latest unique weapon is.
However, I'm not sure if I'm doing the comparisons effectively. There are factors like overall damage, attack speed, etc to consider, and I have only really just been focussing on the overall damage that the weapon (or weapons if dual wielding) can deal.
So what collection of information/calculations should be considered when selecting new weapons?