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I've been thinking of creating a stealth/ Syringer Rifle character build for Fallout 4. The general idea is a character who relies on short range stealth melee and long range Syringer Rifle attacks to get by.

The Syringer Rifle is different from every other Fallout 4 weapon (I know of) in that you have to craft your own ammo - and most of the Syringer Ammo is non-lethal.

This makes me wonder about what Fallout 4 Perks apply to the Syringer Rifle. For example does Riflesman or Ninja increase the damage for Bleed-out or Radscorpion venom syringes?

And does Luck have any effect on the syringes with "Chance" effect? If I select a Critical in VATS will the "Chance" effect always be applied?

What perks apply to the Syringer Rifle in Fallout 4?

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    In all the time I've played this game, I've never bothered using the Syringer Rifle. I better investigate.
    – DCShannon
    Sep 8, 2016 at 21:05
  • @DCShannon - me neither. But I thought it might make an interesting build. I'm enjoying builds with artificial constraints at the moment to keep the challenge up.
    – BaronGrivet
    Sep 9, 2016 at 3:07
  • Making a melee character on survival was pretty challenging. Up until around level 30. Not too long after that I was more deadly than my shooter builds. 12x sneak attack is devastating.
    – DCShannon
    Sep 9, 2016 at 19:54

3 Answers 3

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According to the Syringer page on Nukapedia,

The Syringer does not benefit from Quick Hands, Rifleman, Mister Sandman, Bloody Mess, or Ninja, but Sniper 1 and 3 both work.

It's not automatic or a pistol, so Gunslinger and Commando wouldn't work either.

Sniper 1 is

It's all about focus. You have improved control and can hold your breath longer when aiming with scopes.

and Sniper 3 is

Non-automatic, scoped rifles gain +25% accuracy to head shot in V.A.T.S.

I can't find any information on critical hits with the Syringer at all. Not sure if it has any effect. Needs testing.

If luck improves your % chance for the rifle's random effects, I see no evidence to that effect.

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According to the wikia, there are confirmed perks that do not work with the Syringer...

The Syringer does not benefit from Quick Hands, Rifleman, Mister Sandman, Bloody Mess, or Ninja, but Sniper 1 and 3 both work.

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    Jinx (plus more characters)
    – DCShannon
    Sep 8, 2016 at 21:10
  • 4
    @DCShannon well this is awkward
    – Vemonus
    Sep 8, 2016 at 21:12
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    I did say I was going to investigate.
    – DCShannon
    Sep 8, 2016 at 21:13
  • I at least hyperlinked all the perks in my answer :p
    – Timmy Jim ♦
    Sep 8, 2016 at 21:13
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According to the wiki:

The Syringer does not benefit from Quick Hands, Rifleman, Mister Sandman, Bloody Mess, or Ninja, but Sniper 1 and 3 both work.

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