In Fallout 4 (PC), is there a way to switch to play as Nora, mid game, after you've already been playing as Nate?
Will this break anything?
You can do this using console:
Press the console button (usually its the "~") and type: "sexchange" to change your gender. You can change your look either again via console (I believe it is "showlooksmenu player 1") or visit a doctor in Diamond City.
I've tried this in the past (although relatively early in the game), there were no consequences.