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I have been interested in playing The Binding of Isaac since quite a while, but I wonder if playing via keyboard might be a disadvantage in-game. It looks kind of Twin-Stick like...

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  • As long as your keyboard doesn't ghost keys: yes, it's well playable.
    – Zeta
    Commented Jan 14, 2018 at 18:49
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    What counts as, "well-playable"?
    – Frank
    Commented Jan 14, 2018 at 18:55

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Yes, it's playable with keyboard.

Moreover, on Steam store page this game doesn't even have 'Full controller support' tag. So there is no advantage in playing with controller.

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