How do I beat the Picus boss?
I have a heavy rifle with about 170 ammo, no grenades, no typhoon aug.
How do I kill her? I tried just putting all the heavy rifle ammo into her but she kills me before I can unload one clip.
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There are lockers around the room with EMP grenades and ammo/weapons in them.
You can knock her out with the EMPs (though be careful to not knock your augmentations out at the same time) and then unload all you've got while she's paralyzed. Repeat as needed.
Try to always stay on the move and don't let her get close to you. You should be able to stay moving long enough to heal up in-between the "paralyze and shoot" rounds. I also recommend saving after each round, so you don't have to restart all the way from the beginning of the fight if things go sour.
There are two ways to kill her:
One is to collect the EMP grenades scattered between the generators. Throw an EMP grenade and unleash lead to kill her (as mentioned by Anna Lear).
Or the second option, which is a lot easier, is to get the EMP shielding upgrade for the Dermal Armour (if you do not have this upgrade, load an earlier save if you have one and upgrade). With this upgrade you can shoot the generators which will cause an EMP burst which will immobilise her and you will be free to shoot her, because you have the EMP shielding augmentation you will NOT be affected by the EMP burst. I found this boss the easiest of the bunch because of this augmentation.
There are several good ways. See the Deus Ex Wiki for a fairly comprehensive list (under Fedorova Tactics).
I've played through the game 6 times, and now I always rely on the stun gun: the boss battles frankly annoy me, and I've found stun gun to be the simplest, most mindless way to end this one. Just shoot it enough times—about 25 times on normal difficulty I believe— and then you get to return to the "real" game. Even if I don't need the stun gun for anything else, it's worth it to carry one for this and certain other encounters.
Ok, I was stuck on this for ages as I had no grenades at all. All you have to do is this: lay an emp mine near one of the 4 generators around the outer circle. Let her rush up to you with her attack near the mine, but stand back enough so you aren't killed.
In the lockers there are health kits and hypnotism sticks so make sure you have one of these to use straight away so you are not killed by the electricity from the exploded generator.
Now While she is stunned you just need to pump about 6 times with the stun gun and she dies. The trick is to make sure you aren't killed by the electricity in the first instance.
The P.E.P.S. is good for this since it stuns her for several seconds. Stun her, switch weapons and shoot her. There's a glitch way to do it on the PC version at least. Stun her with the P.E.P.S. then run up to her and crouch. She can't seem to attack you in that situation and she's stuck. Then you can whittle her down with the pistol or something else if you like.