Lately in LotV, I've seen professional Zerg players build their lair at their natural (at least, against Terran) rather than in their main base. Why? Wouldn't the main be a safer choice?
Safer but not Stronger
According to this Reddit Post:
Most people that lair at the nat in ZvP and ZvT do it because it's easier to defend and less likely to be dropped, which is also why many people don't throw all their tech buildings in the main either. Side benefits are that it also punishes a terran that scans the main instead of the natural.