I am looking at the Cliffs Of Dover. If I were to drop a settlement on one of the tiles of it, would the city have the usual 2 food, 1 production -- and the two gold and the three culture? That'd be sweet.
You cannot build cities, wonders, or districts on top of natural wonders. Their bonuses are either flat bonuses or tile based bonuses where they boost at least 1-4 spaces around them.
The Cliffs of Dover are no exception and
"cannot be developed or improved. Because of this, the Cliffs may be more of a hindrance than an asset later in the game"