Currently on Chapter 4, and while exploring around some of the abandoned houses in the West End, I found a house broken open with blood stains everywhere. On walking in, my character remarked on the blood, and a quest called "Like Father, Like Daughter" was added to my log with an accompanying 'citizen in peril' (the head with an exclamation point) icon on my map in a very out-of-the-way location - the kind that means you need to save them tonight or they're gone for good.
Looking it up, it seems the character is Louise Teasdale and she's trapped in the sewers. I really want to rescue her, but all the game guides seem to suggest I should be exploring the sewers during Chapter 5 and first encountering her then.
This leaves me with two questions: A) can I explore the West End sewers now and rescue her in Chapter 4? and B) if I can't, will progressing the game until chapter 5 without manually resting count as going to a new night (and cause her death), or can I make it to Chapter 5 and rescue her then?