The game can feel a bit like a slog with how realistic and slow it is for animations and traveling. I was wondering if I power through the main story will I remove my ability to complete certain side content because it is time sensitive to where you are in the main story? Thanks.
There is at least one achievement/trophy you can miss if you simply power through the story: you need to fulfill 5 camp companion requests and will not be able to do this if you progress all the way to the epilogue. You can also miss opportunities asking since some companion requests are restricted to specific camps.
There are some other side missions that are chapter specific, as time does pass at the rate of weeks, months, and even years through the story.