In The Legend of Zelda: Skyward Sword, is it possible to play the game with a left-handed Link? Obviously, I can switch hands I use for the Wiimote and nunchuck, but that won't change how Link appears on-screen.
No, there's no left-handed mode, although there were lots of rumours. This IGN editor's note confirms that from Nintendo itself.
When sites started reporting our "news" we immediately started to have second thoughts. Was there a left-handed mode? We consulted our combined 50 pages of notes and realized we had made no such observations. That lack of evidence caused me to quickly send an inquiry to Nintendo for extra verification. However asking Nintendo a question can take a little while, particularly if it's something a bit off the radar or about a very specific game detail...
...Late, late last week I heard back from Nintendo that there was no so such mode.