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In Mediterranean Defense, I have three assassins assigned to one city, but when I try to send them on missions it turns out that the first one is unavailable. I can't even move the cursor over him and there's no indication of why.

Is the first assassin assigned to a city always unavailable? Is there any reason for that?

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The first one is the den master and cannot be sent on missions, you can only send the other assassins assigned to the city (up to 4)

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    This isn't exactly accurate - they're not den masters in the sense that your dens in Constantinople have masters. You CAN switch them out, you just have to leave at least one assassin in the city. – Shinrai Dec 20 '11 at 16:05

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