I have played just about every MOBA game to date. Using numpad 789456 simply doesn't work for item hotkeys. I like the way LoL uses 1-6 for item hotkeys, and I like the way SC/War3/DotA uses 1-6+ for control groups. I would like to use 1-6 for my items, but then that takes away my ability to use those for control groups. I know not a lot of heroes have the need for control groups, but I can't help but feel like I shouldn't change them and that I'm stuck in terms of what to do with my hotkeys. I have heard of suggestions of alt+QWEASD, but that takes away hotkeys that are used for toggling autocast.
Are there any alternatives I'm unaware of or are not remembering?