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I've just finished the mission: "The Shroud" which involves distributing the Krogan Genophage cure.

Unfortunately, this mission ended with the loss of Salarian life

-- one of my favorite Mass Effect characters, Mordin Solus.

Is there a way to complete this mission that doesn't involve the death of our Salarian friends?

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Everyone's favorite patter-singing Salarian Scientist can be saved...

But the price, and required setup is arguably too high:

In order to keep Mordin alive, you need to have 1) Not saved Maelon's data in ME2, and 2) Urdnot Wreav must be the leader of the Krogans (that is, Wrex must have died on Virmire in ME1).

Incidentally, this is the default state for a new, non-imported Shepard. Under those circumstances, and only under those circumstances,

Mordin can instead be persuaded to lie to the Krogans about the Genophage cure, and they will buy it, hook, line, and sinker. At this point, you gain both the Krogans and Mordin as War Assets.

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    I forget, is it possible to complete Mordin's loyalty quest without gaining Mordin's loyalty? If so, this seems relatively easy for a Renegade Shep to do.
    – MBraedley
    Commented Mar 9, 2012 at 16:57
  • @MBraedley no, Mordin has no rivals in ME2 so you don't have a chance to make him lose the loyalty.
    – l I
    Commented Mar 9, 2012 at 22:35
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    I love Mordin, but no way would I kill off Wrex to keep Mordin alive.
    – rshea0
    Commented Mar 11, 2012 at 7:27
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    The question was about both curing genofage (not faking it) and saving Mordin. This is impossible.
    – Alien-47
    Commented Jun 19, 2012 at 21:05
  • Too bad that one of my favorite characters is Wrex.
    – Adam Arold
    Commented Jul 28, 2015 at 20:19
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I saw on a forum somewhere that it is possible.

You can convince Mordin to sabotage the cure, but Eve will die. You also lose the support of Wreav. However, either way you choose to go (sabotage or not), you can regain the support of the lost faction in another quest (so I'm told).

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    This is correct, and really, it's just another way of stating the conditions noted in my answer. Wreav won't be in charge if Wrex is alive, and if you completed Mordin's loyalty mission in ME2, Eve won't die.
    – LessPop_MoreFizz
    Commented Mar 8, 2012 at 5:48
  • +1 for only one to mention the support of the lost faction...
    – BlueRaja - Danny Pflughoeft
    Commented Jul 29, 2012 at 21:19
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You can complete Mordin's loyalty mission, but you need to destroy Maelon's data about curing the Genophage (this will get eve to die in me3). Wrex needs to die in ME1, but it has nothing to do with Mordin being loyal in ME2.

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One of my friends was able to use the paragon option to save mordin. I dont know how he did it. When I played it that option never came up.

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    That option comes up if and only if Wrex and Eve are dead, at which point it's possible to argue to him that with Wreav in charge curing the genophage will restart the Krogan Rebellions.
    – Shadur-don't-feed-the-AI
    Commented May 8, 2012 at 5:33
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Nope. This is the cost of curing the genophage.

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