Note: Here be spoilers. I couldn't really figure out a way to ask this without them.
My Shepard is a female who plays (mostly) Renegade and also romanced Thane in Mass Effect 2. I have no idea if this plays out differently depending on whether or not you gained Thane's loyalty in 2, but for the record, I did.
After the attack on the Citadel and Thane becomes hospitalized, you can go see him. Depending on the option when Kolyat asks if you want to join him in prayer or not, the lines of the prayer Kolyat says change.
Renegade choice (declining):
Kolyat: Kalahira, this one's heart is pure, but beset by wickedness and contention. Guide him to where all hunters return, where all storms become still, where all stars show the path. Guide him, Kalahira, and he will be a companion to you as he was a father to me.
This version is obviously from Kolyat's point of view.
Paragon choice (joining):
Kolyat: Kalahira, this one's heart is pure, but beset by wickedness and contention.
Shepard: Guide this one to where the traveler never tires, the lover never leaves, the hungry never starve.
Kolyat:Guide this one, Kalahira, and she will be a companion to you as she was to me.
After this version, Shepard asks Kolyat why the end of the prayer used "she," and he responded:
The prayer was not for him, Commander. He has already asked forgiveness for the lives he has taken. His wish was for you.
How does the Paragon version of the prayer differ? I suspect that the line "Kalahira, this one's heart is pure, but beset by wickedness and contention" may differ based on whether or not your Shepard is Paragon or Renegade. In addition, how does the ending of this prayer change if you were either a female who did not romance him or were male?
Having to replay this scene over and over to screencap the dialogue for transcription may or may not have resulted in teary-eyed sniffles.