In League of Legends, the case is usually that players will be facing off against each other at the beginning of the game in the Lane phase, a part of the game that relies heavily on individual strengths and weaknesses of both players and champions.
With that, some Champions skill sets may give players an advantage or handicap on their opponents champion, with Skill of the player acting as a different variable as their skill is translated through that champion.
So, if there are 2 skilled players playing one another, should the second pick play the "Counter Pick" champion and sacrifice his personal skill for champion advantage or play a Champion they are comfortable with and disregard the match up between champions?