What's the most reliable way to achieve "Massive Blow"?
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This can be easily achieved in the cathedral, with the wizard.
After you get to level 10+ go around the cathedral (whichever level) and gather up a few monsters.
After that, use frost nova to stun them and deal some damage, and then use wave of force to kill them all with one blast.
This is the way i did it and everything went incredibly smoothly.
Hope i could help, cheers :)
Another option is to find the Jar of Souls event and wait for lots of things to spawn.