I've just picked up Okami HD and like any sane person would, I love it. They've added trophies now as well, which is great. But with this type of game, especially with a design that's a decade old and never included any meta-game stuff like trophies to begin with, I'm not sure how easy it will be to get all the trophies in one playthrough. I remember the game being really long, too, so I imagine it would be quite annoying to miss just one!
Are there any trophies that can be accidentally permanently missed in the game, due to things like inaccessible areas, enemies, one-time events, etc? If so, can we abuse the manual save system to get another chance? Are there certain points where I should create a separate save to be able to access those events/enemies?
I've played the game before but I'm sure plenty of people haven't, so use spoiler tags where appropriate, please!