Beam or gas attacks are normally unblockable, but can be blocked with Guard Up. This includes:
- Pukei-Pukei's poison cloud
- Radobaan's and Uragaan's sleep clouds
- Uragaan's fire cloud
- Kirin's lightning attack that hits a long area across the ground
- Teostra's supernova
- Vaal Hazak's beam attacks
- Xeno'jiiva's beam attacks
- Kulve Taroth's lingering fire pools
- Lunastra's fire puddles igniting from a different fire attack
- Behemoth's ground shockwave
Additionally, some attacks can not be blocked even with Guard Up, such as:
- Behemoth's horn impale
- Behemoth's Ecliptic Meteor
- Ancient Leshen's "bird nova", the attack that sends out Revoltures in all directions after charging up