It is a good buy versus anyone who has ultimates or abilities that rely on health regeneration.

The active makes this item extremely effective against champions with healing abilities, as well as the use of health potions. It is also effective against champions and item builds that rely on spell vamp and/or life steal. 

Examples of champions/abilities/items that it counters include:

 - Health Potion
 - Dr. Mundo's  Sadism
 - Fiddlesticks's  Drain
 - Soraka's  Astral Blessing and  Wish
 - Swain's  Ravenous Flock
 - Warwick's  Hungering Strike and  Infinite Duress
 - Sion during  Cannibalism
 - Tryndamere's  Bloodlust
 - Renekton's  Cull the Meek
 - Volibear's  Chosen of the Storm
 - Vladimir's Transfusion
 - The Bloodthirster /  Sanguine Blade
 - Summoner Heal

[Source][1]

So, if there is particularly abusive Swain, Warwick, or Sion then it can help stop them.


  [1]: http://leagueoflegends.wikia.com/wiki/Executioner%27s_Calling