From the Mass Effect 2 Wikia [Romance page][1]: > For a male Shepard, a love interest is "locked in" once you express > interest at the following dialogue points: > > - Jack: "I want to talk about us." At the point where she says "I'm not interested in some dumbshit love affair. It never goes right." > To prevent locking-in, say "Never mind". > > - Tali: "I want to talk about you." At the point where she beckons you toward the drive core and says "I've been thinking about the > last time we talked." To prevent locking-in, say "So you're not > interested?" followed by "I need to think about this." > > - Miranda: "Can we talk?" At the point where she says "I don't know what this is, if it's just stress, or blowing off steam, or..." you > cannot opt out; every option results in either becoming locked-in, or > the relationship being broken off permanently. It is recommended that > the player save before talking to Miranda. > > At this point you know that Shepard has successfully 'locked in' that > romance. Shepard can still express an interest in other crew members. > However, the new love interest will 'challenge' Shepard's > love-triangle and force Shepard to dump the 'locked-in' option in > order to be with them. I've only tried to romance Miranda (and apparently after trying that I was locked-in no matter what), but I did also get the Jack dialog. For more information (about Kelly and Samara/Morinth), you should check out the romance page for yourself. There's a bit about loyalties on there as well. [1]: http://masseffect.wikia.com/wiki/Romance