During the final chapter of the game you have to choose between saving Trish or saving doctors from one of two buildings. The game claims you have enough time only for one or the other. It also presents a karma choice moment.
It seems that both choices are technically good. I'd think the evil choice would be to have a beer and let both the doctors and Trish dangle to their deaths.
If I'm trying to maintain good karma as far as the plot is concerned, which choice should I make?