If I'm fighting Mutons, Heavy Floaters, or Cyberdiscs, they will tend to eschew their primary attack in favor of hucking a grenade in my general direction if my squad is spaced together too tight.
I know that there's a non-zero chance that they will just grenade one of my squad members anyway, but is there a good rule of thumb for how far apart my squad members should be in order to avoid a guaranteed grenade? I assume it must be related to the radius of the grenade's blast, but I rarely use grenades myself so I don't have this info committed to memory already.