I've pretty much got the build you're looking for, except with shakier morals (if it's not nailed to the floor it's going into my pocket).
I've focused on one-handed and heavy armour (go for lots of perks in these trees, esp. One Handed to maximise damage), as well as restoration and destruction (the latter to a lesser degree as it becomes considerably less efficient than high-level weapons). One perk I found incredibly useful is Respite in the Restoration tree, as it heals Stamina as well as Health. Useful for all sorts of things, from cross-country travel (sprint, heal to restore, keep sprinting - if you have high magicka regen you can cover great distances without stopping) to staying dangerous (power attacks nearly always available).
Also go for the perks that make Restoration spells cheaper as it will keep your magicka reserves usable for longer.
As I mentioned in my comment to Hackworth, I've never used a shield in the game. There have been times when they would have been useful (dragons, etc) but that was mostly early in the game. By now (level ~45) I've got great dragon armour and high damage output so very few enemies pose a significant threat unless I'm careless.
Addendum: Potions are a great way to make money and can be very useful, but again, I keep stockpiling them and eventually selling them off. I can heal efficiently so rarely need healing/magicka/stamina potions. Resistances and poisons are usually not needed as the enemies are not threatening for very long :)