Are there hidden setting in Starcraft 2 to set the mouse button to default to "attack-move" instead of the standard move command, where the enemies are ignored and the units are running blind into their dead just to reach the point on the map, you clicked on?
Consider using a keyboard-mouse macro. If you are using a proper gaming mouse and keyboard you could program a simple conditional like:
IF Left-Click then Enter Character 'A'
Thus, every time you you left-click you would automatically enter attack move mode if you have one or more units selected. But as Nick122 has warned, there may be unforeseen consequences such as attacking a gas refinery that you intended to harvest from if you are selecting SCVs, although when you mine minerals or gas you usually right-click... but still...
If you are serious about this I recommend programming a macro like the one I described, and testing this for yourself if you have a gaming keyboard and mouse which have this as a native feature. Otherwise, you would need to get third-party macro software for your mouse and keyboard which would need to run in the background while you play Starcraft II.
My verdict: an interesting notion but not worth the effort. If you want to optimize your game-play there are other useful things you can do. I play Zerg and have set my space-bar key to rotate between hatcheries for faster injecting, for example. If you do test this out, post the results here. I for one, would be interested.