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How can I most efficiently find the House of Curios in Diablo 3 v2.6.1?

I found How can I find the House of Curios? but it appears that changing what quest you're on no longer matters for starting a game instance. Do you always start in town now?

Is there a consensus on whether finding the Scavenger's Den and Lost Mine rule out having a House of Curios on that map?