tl;dr: There are no relays in Andromeda and leaving Heleus is highly infeasible for the time being.
The Mass Relays are Reaper tech and the Reapers were located in the Milky Way (dormant in the nearby empty space). There are no relays in Andromeda or on the way so they had to use standard FTL transport, hence why it took 600 years to get there. This is confirmed throughout the game during Ryder's conversations.
They are low on fuel and resources so travelling to a different cluster inside Andromeda is not possible, hence they're stuck in Heleus for the time being. They could fuel up with the help of the Angara, go back in cryo and point themselves somewhere else but why would they do that? They surveyed the galaxy and the Heleus cluster was the most viable so they already are in the best place they know. Flying somewhere else would imply the same risks they took when flying to Heleus (such as hitting the scourge). Not to mention that they're still not sure what happened to the rest of the arks and leaving them behind would cause a lot of anger among the sleeping "relatives" of the people left behind, including those of the exiles left in Heleus.
They could also point themselves back to the Milky Way but then it would all be in vain. Thousands of people dead and the only achieved thing would be a jump 1200 years into the future. Not to mention that they were unable to communicate with them so many things could have happened in 1200 years and the Milky Way could be all but destroyed by war.
Therefore their best bet is making do with what they have in Heleus, get a foothold in there, get fuel and resources, build up their population, military and technology, try to communicate with the Milky Way and scan the rest of Andromeda. Another goal would definitely be to analyze the scourge and stop it from being a problem. They might even be able to work with the races of Heleus to research better travel technology (maybe even as good as the mass relays?) and make Andromeda as nice as the Milky Way.