I am using legacy keys. I have set my item key bindings to legacy (numpad keys) + quickcasts are set as presented above.
Yet I still have ZXCVVBN keys bound as item keys, the chat wheel resets to Y key, which makes a lot problems especially when playing invoker which in legacy mode uses V for ghost walk, B for deafening blast and Y for cold snap.
The problem occured after new layout had been introduced, disappeared for a while and now returned to it's broken state.
I usually deal with it by setting the 'Y' key or w/e to something and then reset it to none, the problem disappears until dota is restarted.