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This seem impossible to me wherever I start, because Madagascar always seem to survive.

Only once have I infected all countries, but the vaccine finished me off before I could win.

How can I make a virus that doesn't succumb to the vaccine so quickly?

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    I have modified your question to highlight the main problem you were having. General tips don't work very well for Arqade. I haven't played this, though, so I don't even know if its possible, so feel free to re-word it. – Frank Dec 29 '13 at 0:28
  • but isn't this a discussion forum? – ijfisjfsai Dec 29 '13 at 0:30
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    Nope. Please take our about tour to understand what we do. – Frank Dec 29 '13 at 0:30
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In order to make your virus resist vaccines, research the "Drug" resistance under the disease tab, as shown below.

Drug resist location

The higher the drug resistance level, the more likely your disease is to beat the vaccine.

Source: Personal experience and this guide

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