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This seem impossible to me wherever I start, because Madagascar always seem to survive.

Only once have I infected all countries, but the vaccine finished me off before I could win.

How can I make a virus that doesn't succumb to the vaccine so quickly?

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    I have modified your question to highlight the main problem you were having. General tips don't work very well for Arqade. I haven't played this, though, so I don't even know if its possible, so feel free to re-word it.
    – Frank
    Commented Dec 29, 2013 at 0:28
  • but isn't this a discussion forum?
    – ijfisjfsai
    Commented Dec 29, 2013 at 0:30
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    Nope. Please take our about tour to understand what we do.
    – Frank
    Commented Dec 29, 2013 at 0:30

1 Answer 1

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In order to make your virus resist vaccines, research the "Drug" resistance under the disease tab, as shown below.

Drug resist location

The higher the drug resistance level, the more likely your disease is to beat the vaccine.

Source: Personal experience and this guide

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