Are there any quests that I can miss?

Question

Are there any time-based quests that I will not be able to complete once I pass a certain Act of the game? Can I always go back and complete quests?

Answer 1

For most quests you can simply go back if you've missed it. The only exception to this is a questline belonging to a faction that can either be friendly or hostile.

This applies for the following factions:

Vanilla

• Kymon's Chosen
• Orther of Death's Vigil
• The Outcast

Ashes of Malmouth

• Barrowholm

If you chose to become enemies with one of the factions mentioned above you will not be able to play their questline in the current playthrough.
This means you can still become allied with them in a later playthrough though.